Leukeran (Chlorambucil) Oral: Use, Aspect Results, Dosage

Leukeran (Chlorambucil) Oral: Use, Aspect Results, Dosage

What Is Leukeran?

Leukeran (chlorambucil) is an oral medicine within the class of antineoplastics, extra particularly, an alkylating agent. It is used to deal with sure kinds of cancers, together with persistent lymphocytic leukemia (CLL), Hodgkin lymphoma, in addition to some kinds of non-Hodgkin lymphomas.

Leukeran works by slowing down the expansion of most cancers cells. It isn’t a treatment for these illnesses, however it may assist deal with them and probably cut back some signs.

Leukeran has the potential to trigger different cancers, although how a lot Leukeran contributes to this threat is unknown. Nonetheless, you possibly can speak to your healthcare supplier about all potential security concerns when beginning remedy. 

Leukeran is obtainable in pill kind to take by mouth.

Drug Information

Generic Title: Chlorambucil

Model Title(s): Leukeran

Drug Availability: Prescription

Administration Route: Oral

Therapeutic Classification: Antineoplastic

Accessible Generically: No

Managed Substance: N/A

Lively Ingredient: Chlorambucil

Dosage Type(s): Tablets

What Is Leukeran Used For?

Leukeran treats several types of leukemia and lymphoma, similar to CLL, Hodgkin lymphoma, and a few types of non-Hodgkin lymphoma, similar to large follicular lymphoma.

When it’s used for Hodgkin lymphoma, it’s utilized in mixture with chemotherapy medicines.

Methods to Take Leukeran

Leukeran needs to be taken as soon as a day. Drink loads of fluids to assist forestall uncomfortable side effects except directed in any other case by your healthcare supplier. It’s best taken on an empty abdomen, as having meals within the abdomen can lower how a lot of the drug is absorbed.

Along with taking Leukeran as prescribed, you may must bear some essential routine lab assessments throughout remedy. These assessments embrace an entire blood rely (CBC) to intently monitor the white blood cells, purple blood cells, and platelets and testing to guage liver operate.


Hold your medicine in its unique container and retailer it within the fridge between 36 F and 46 F. Make sure that the container is saved out of attain of kids and pets.

Leukeran ought to solely be dealt with by the individual taking the medicine. Wash your arms completely after dealing with it.

Off-Label Makes use of 

Healthcare suppliers could prescribe chlorambucil for off-label makes use of, that means for situations not particularly indicated by the FDA.

There are just a few off-label makes use of for which chlorambucil is a remedy possibility. These embrace:

  • Idiopathic membranous nephropathy, which impacts the filtering items (glomeruli) contained in the kidney
  • Necrobiotic xanthogranuloma, the irregular improvement of lesions across the eyes because of the overgrowth of tissue
  • Waldenstrom’s macroglobulinemia, a kind of lymphoma that causes massive quantities of irregular proteins to build up within the blood

How Lengthy Does Leukeran Take to Work?

Leukeran is shortly absorbed as soon as it enters the gastrointestinal tract. Nevertheless, it could take just a few weeks or months of remedy earlier than any enchancment is seen.

What Are the Aspect Results of Leukeran?

This isn’t an entire checklist of uncomfortable side effects, and others could happen. A healthcare supplier can advise you on uncomfortable side effects. When you expertise different results, contact your pharmacist or a healthcare supplier. You could report uncomfortable side effects to the FDA at www.fda.gov/medwatch or 800-FDA-1088.

Widespread Aspect Results 

The widespread uncomfortable side effects related to Leukeran embrace:

Extreme Aspect Results 

Name your healthcare supplier instantly in case you have severe uncomfortable side effects. Name 911 in case your signs really feel life-threatening or for those who suppose you’re having a medical emergency. Severe uncomfortable side effects and their signs can embrace the next:

  • Bone marrow suppression, which can trigger signs of fatigue, pale pores and skin, elevated coronary heart price, dizziness, and shortness of breath
  • Seizures
  • Interstitial pneumonitis (irritation of the lungs)
  • Pores and skin hypersensitivity, together with uncommon studies of Stevens-Johnson syndrome, which may trigger flu-like signs and a painful, blistering rash

Lengthy-Time period Aspect Results

Lengthy-term uncomfortable side effects from Leukeran can happen.  These long-term results can embrace the next:

Report Aspect Results

Leukeran could trigger different uncomfortable side effects. Name your healthcare supplier in case you have any uncommon issues whereas taking this medicine.

When you expertise a severe aspect impact, you or your healthcare supplier could ship a report back to the FDA’s MedWatch Opposed Occasion Reporting Program or by telephone (800-332-1088).

Dosage: How A lot Leukeran Ought to I Take?

Drug Content material Supplied and Reviewed by

IBM Micromedex®

The dose of this medication will probably be totally different for various sufferers. Comply with your physician’s orders or the instructions on the label. The next info consists of solely the typical doses of this medication. In case your dose is totally different, don’t change it except your physician tells you to take action.

The quantity of drugs that you simply take will depend on the energy of the drugs. Additionally, the variety of doses you’re taking every day, the time allowed between doses, and the size of time you’re taking the drugs depend upon the medical downside for which you might be utilizing the drugs.

  • For oral dosage kind (tablets):

    • For persistent lymphatic leukemia and different kinds of lymphoma:

      • Adults—Dose is predicated on physique weight and have to be decided by your physician. The dose is normally 0.1 milligram (mg) per kilogram (kg) of physique weight per day, taken as a single dose, for 3 to six weeks.
      • Kids—Use and dose have to be decided by your physician.
    • For remedy of Hodgkin’s illness:

      • Adults—Dose is predicated on physique weight and have to be decided by your physician. The dose is normally 0.2 milligram (mg) per kilogram (kg) of physique weight per day, taken as a single dose, for 3 to six weeks.
      • Kids—Use and dose have to be decided by your physician.


Sure components could have an effect on your dosage of this medicine.

That is usually attributable to considerably decreased blood cell counts. The dimensions of the dose or how often the dose is taken could also be modified primarily based on blood assessments.

Dose modifications might also have to be made if liver operate is lower than standard.

Missed Dose 

When you miss a dose, take it as quickly as you keep in mind. Nevertheless, whether it is nearer to the following dose than the missed one, skip it and proceed together with your common dosing schedule. By no means double up on a missed dose.

Overdose: What Occurs If I Take Too A lot Leukeran?

Instantly notify your healthcare supplier for those who take an excessive amount of Leukeran is taken. An excessive amount of of this medicine could cause vital and probably life-threatening results.

Overdosing on Leukeran could outcome within the following:

  • Pancytopenia (low ranges of all kinds of blood cells)
  • Agitation
  • Ataxia (lack of coordination)
  • Seizures

Within the occasion of an overdose, you’ll doubtless be monitored by a healthcare supplier and handled appropriately.

What Occurs If I Overdose on Leukeran?

When you suppose you or another person could have overdosed on Leukeran, name a healthcare supplier or the Poison Management Heart (800-222-1222).

If somebody collapses or is not respiratory after taking Leukeran, name 911 instantly.


Drug Content material Supplied and Reviewed by

IBM Micromedex®

It is rather essential that your physician test your progress at common visits to ensure this medication is working correctly. Blood assessments will probably be wanted to test for negative effects.

Utilizing this medication if you are pregnant can hurt your unborn child. Use an efficient type of contraception to maintain from getting pregnant. When you suppose you may have grow to be pregnant whereas utilizing this medication, inform your physician straight away.

When you plan to have kids, speak together with your physician earlier than utilizing this medication. Some women and men utilizing this medication have grow to be infertile (unable to have kids).

Severe pores and skin reactions can happen with this medication. Cease utilizing this medication and test together with your physician straight away in case you have blistering, peeling, or loosening of the pores and skin; purple pores and skin lesions; extreme pimples or pores and skin rash; sores or ulcers on the pores and skin; or fever or chills if you are utilizing this medication.

If you are being handled with chlorambucil, and after you cease remedy with it, shouldn’t have any immunizations (vaccinations) with out your physician’s approval. Chlorambucil could decrease your physique’s resistance and there’s a likelihood you may get the an infection the immunization is supposed to stop. As well as, different individuals dwelling in your family shouldn’t take oral polio vaccine since there’s a likelihood they may cross the polio virus on to you. Additionally, keep away from individuals who’ve taken oral polio vaccine throughout the final a number of months. Don’t get near them, and don’t remain in the identical room with them for very lengthy. When you can not take these precautions, it’s best to think about carrying a protecting face masks that covers the nostril and mouth.

Chlorambucil can briefly decrease the variety of white blood cells in your blood, growing the possibility of getting an an infection. It will probably additionally decrease the variety of platelets, that are crucial for correct blood clotting. If this happens, there are particular precautions you possibly can take, particularly when your blood rely is low, to cut back the chance of an infection or bleeding:

  • When you can, keep away from individuals with infections. Examine together with your physician instantly for those who suppose you might be getting an an infection or for those who get a fever or chills, cough or hoarseness, decrease again or aspect ache, or painful or tough urination.
  • Examine together with your physician instantly for those who discover any uncommon bleeding or bruising; black, tarry stools; blood within the urine or stools; or pinpoint purple spots in your pores and skin.
  • Watch out when utilizing a daily toothbrush, dental floss, or toothpick. Your medical physician, dentist, or nurse could suggest different methods to wash your tooth and gums. Examine together with your medical physician earlier than having any dental work carried out.
  • Don’t contact your eyes or the within of your nostril except you may have simply washed your arms and haven’t touched anything within the meantime.
  • Watch out to not reduce your self if you find yourself utilizing sharp objects similar to a security razor or fingernail or toenail cutters.
  • Keep away from contact sports activities or different conditions the place bruising or damage may happen.

Examine together with your physician straight away in case you have the next signs whereas taking this medication: pores and skin rash, fever, cough that will not go away, irregular month-to-month interval, nausea or vomiting, seizures, uncommon lumps, or yellow eyes or pores and skin.

Make sure that your physician is aware of in case you have had some other most cancers remedies or radiation remedy throughout the previous 4 weeks.

Most cancers medicines could cause diarrhea, nausea, or vomiting in most individuals, generally even after receiving medicines to stop it. Ask your physician or nurse about different methods to manage these uncomfortable side effects.

What Are Causes I Shouldn’t Take Leukeran?

Don’t take Leukeran if you are pregnant or breastfeeding.

It must also not be taken by anybody allergic to lively or inactive components.

What Different Drugs Work together With Leukeran?

Earlier than beginning remedy, inform your healthcare supplier about all of your medicines, together with prescription and over-the-counter (OTC) medication, nutritional vitamins, or natural dietary supplements.

Leukeran needs to be used cautiously in individuals on different medicines identified to trigger low blood counts.

Additionally, keep away from getting any reside vaccines throughout your remedy. The antibody response of those vaccines could not work as nicely. Look forward to a reside vaccine no less than three months after your final spherical of chemotherapy.

What Drugs Are Comparable?

Many different medicines fall into the group of alkylating brokers. These are used for varied cancers, and never all for the precise kinds of cancers Leukeran is used for. These medicines embrace:

  • Belrapzo, Bendeka, Treanda (bendamustine)
  • Carboplatin
  • Cisplatin
  • Cytoxan (cyclophosphamide)
  • Eloxatin (oxaliplatin)
  • Ifex (ifosfamide)

Often Requested Questions

  • What’s Leukeran used for?

    Leukeran is used for sure kinds of lymphomas, similar to Hodgkin’s lymphoma, in addition to some kinds of non-Hodgkin lymphoma and a kind of leukemia known as CLL.

  • How does Leukeran work?

    Leukeran works by interfering with DNA or RNA contained in the most cancers cell. The harm that Leukeran causes prevents the cells from having the ability to divide usually.

  • What medication shouldn’t be taken with Leukeran?

    Dwell vaccines needs to be averted whereas taking Leukeran.

  • How do I cease taking Leukeran?

    Don’t cease taking Leukeran except instructed by your healthcare supplier. Notify your healthcare staff instantly if you’re experiencing any vital uncomfortable side effects.

How Can I Keep Wholesome Whereas Taking Leukeran?

Beginning most cancers remedy can appear overwhelming. There may be usually lots of info to digest. Do not forget that your most cancers care staff will reply your questions and aid you higher perceive your medicines throughout this time.

Dwell vaccines shouldn’t be obtained throughout your remedy course and for 3 months after. That is because of the threat of an infection from viral shedding. Moreover, the medicine can intrude with how nicely the vaccine works. Earlier than beginning remedy, work together with your healthcare supplier to make sure you are up-to-date on all crucial immunizations. Some vaccinations are beneficial throughout most cancers remedy, such because the flu shot.

Whereas taking Leukeran, take note of how you feel. Do not hesitate to report any new or worsening uncomfortable side effects that come up out of your remedy. It is also important to maintain all appointments beneficial by your oncologist, particularly for normal lab assessments.

Medical Disclaimer

Verywell Well being’s drug info is supposed for instructional functions solely and isn’t meant to exchange medical recommendation, prognosis, or remedy from a healthcare supplier. Seek the advice of your healthcare supplier earlier than taking any new medicine(s). IBM Watson Micromedex offers among the drug content material, as indicated on the web page.

Leukeran (Chlorambucil) Oral: Use, Aspect Results, Dosage

By Julie Scott, MSN, ANP-BC, AOCNP

Julie is an Grownup Nurse Practitioner with oncology certification and a healthcare freelance author with an curiosity in educating sufferers and the healthcare neighborhood.